![]() ![]() HRDs represent a broad variety of diseases, encompassing 84.5% of all rare diseases. Hyper-rare diseases (HRD) are a subset of rare diseases with a prevalence of less than 1 in 1,000,000. ![]() This is due to uncertainty about government regulation, uncertainty about insurance coverage, concerns over ethics, but namely a concern about a financial return. There is a current subset of disease that has gone wholly ignored by the pharmaceutical industry. It is no secret pharmaceutical companies take time to commercialize new therapeutics, sometimes for good reason and sometimes for no reason. "How many thousands of people suffered needlessly during the forty-six years between Gerhardt's discovery and Bayer's distribution of aspirin?" Eli Lilly opines in Thea Cooper's book Breakthrough. Rare disease, Neglected rare disease, Commercialization ![]() A subset of rare disease defined hereunto is presented along with a solution to the neglect of development of therapies for this subset. ![]()
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